Kırgızistan’ın yerli halkında lipitler ve leptin düzeyi

Erkin Mirrakhimov, Alina Kerimkulova, Olga Lunegova, Aibek Mirrakhimov, Nazira Alibaeva, Malik Nabiev

Yazar Adresleri
Department of Internal Medicine, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan,
National Center of Cardiology and Internal Disease, Bishkek, Kyrgyzstan,
Kyrgyz-Russian (Slavic) Univeristy, Bishkek, Kyrgyzstan,
Yazışma Adresi
Erkin Mirrakhimov - Togolok Moldo 3 Bishkek, Kyrgyzstan. Tel: +90 996312 663175 e-mail: ermir@infotel.kg
Yayın Tarihi
Teslim Tarihi: 06 Mayıs 2013
Kabul Tarihi: 06 Ekim 2013
Özet
Tam Metin
Kaynaklar

Amaç: Adipositler tarafından salgılanan 167 amino asitli protein olan leptin obezite ile bozulmuş lipit metabolizması arasındaki olası bağlantıyı oluşturur. Vücutta leptinin içeriği beden kütle indeksiyle (BKİ) yakından ilişkilidir. Leptinin dislipidemiyle ilişkisi konusundaki çalışmalardan elde edilen veriler çelişkilidir. Kırgız halkında leptin düzeyi daha önce araştırılmamıştır. Bu çalışmanın amacı Kırgız ırkında leptin ile lipit parametreleri arasındaki ilişkiyi araştırmaktır.

Çalışma planı: Çalışmaya Kırgızistan’da yaşayan ≥30 yaşlarında Kırgız ırkından 322 kişi (145 erkek, 177 kadın) alındı. Antropometrik parametreler [boy, kilo, bel çevresi (BÇ), kalça çevresi (KÇ)] ve kan basıncı (KB) ölçüldü. Laboratuvar testlerinden açlık kan şekeri (AKŞ), lipit profili [total kolesterol (TK), trigliseritler (TG), yüksek yoğunluklu lipoprotein (YYL) kolesterol, düşük yoğunluklu kolesterol (DYL) ve serum leptin ölçüldü.

Bulgular: Serum leptin, her iki cinste BKİ, BÇ, TG ve erkeklerde TK ile pozitif korelasyon göstermektedir.

Sonuç: Leptin, Kırgızlarda her iki cinste BKİ, BÇ ve TK, erkeklerde TK ile ilişkilidir.

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